A Preliminary Report on the Minimum Curative Dose of Quinine in the Treatment of Malarial Fever by the Intravenous Method
نویسنده
چکیده
a day during the second month, then 5 grains twice a day during the third month." In the trea'ment of malarial fever by the intravenous injection of quinine, a method which one sometimes adopts in cases suffering from recurring attacks, the physician has to decide when there has been complete sterilization of the system. Negative results on examination of the peripheral blood are of no help whatever, as it is a well-known fact that the parasites may remain in the internal organs during treatment with quinine, although the peripheral blood may not show the parasites. The complement-fixation test recently introduced by Gordon Thomson of
منابع مشابه
The Treatment of Malarial Fever in Individuals Susceptible to Attacks of Black Water Fever by Intravenous Injection of an Antihæmolytic Quinine Solution
an inhibitory action in a hemolytic system. At the time of the above discussion, I.did not know whether such a solution could be prepared. Cases of hemoglobinuria following administration of quinine in malarial individuals do undoubtedly occur. In some cases, the appearance of the hemoglobinuria may be accidental. Leaving these accidental cases and without entering into the discussion of the me...
متن کاملStudies of Human HbAA Erythrocyte Osmotic Fragility Index of Non-Malarious Blood in the Presence of Five Anti-malarial Drugs
Background: The capacity of human HbAA erythrocytes of non-malarious blood to withstand osmotic stress in the presence of five antimalarial drugs, Chloroquine phosphate, Quinine, FansidarTM, CoartemTM and HalfanTM was studied in vitro. Materials and Methods: Aqueous solutions of four increasing concentrations of the drugs used in this investigation were in the order: 0.2%, 0.4%, 0.6% and 0.8% (...
متن کاملIntramuscular loading dose of quinine for falciparum malaria: pharmacokinetics and toxicity.
In a study of intramuscular injection of quinine eight adults with moderately severe falciparum malaria resistant to chloroquine were treated with quinine dihydrochloride, being given a loading dose of 20 mg salt (16.7 mg base)/kg followed by three or four eight hourly maintenance doses of 10 mg salt (8.3 mg base)/kg injected into the anterior thigh. All patients responded to treatment. Fever a...
متن کاملClinical Pharmacology of the Antimalarial Quinine in Children
Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...
متن کامل